Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma.

نویسندگان

  • Fahimeh Asadi-Amoli
  • Farid Khoshnevis
  • Hayedeh Haeri
  • Issa Jahanzad
  • Reza Pazira
  • Reza Shahsiah
چکیده

Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid. Early diagnosis and proper treatment significantly improve the outcome. SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated. AR was positive in all 19 SEB cases. Of 18 BCCs, 6 (33%) showed focal nuclear immunoreactivity. The 18 SCCs showed no nuclear immunoreactivity. AR is a sensitive marker for SEB, especially in less differentiated tumors. Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Squamous cell carcinoma arising from a Sebaceous cyst

      Abstract: development of squamous cell carcinoma from sebaceous cyst is uncommon.in this report , we report a77- old female patient who has had a sebaceous cyst for 20 years. The cyst started to grow during the last year. The patient underwent an operation for excision biopsy and The diagnosis was squamous cell carcinoma.

متن کامل

Cytodiagnosis of Cutaneous Basal and Squamous Cell Carcinoma

Background and Objective: Cutaneous cytology is the study of scraping or smears obtained from skin lesions. Although not commonly employed, cutaneous cytology has been a useful tool for clinicians due to simplified procedures and high sensitivity and specificity of presurgical clinical diagnosis of commo...

متن کامل

Value of CD10 Expression in Differentiating Cutaneous Basal from Squamous Cell Carcinomas and Basal Cell Carcinoma from Trichoepithelioma

Background: In addition to the well-defined histological criteria for squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), immunohistochemical techniques can be used in difficult cases for their differentiation. As differential diagnosis between trichoepithelioma (TE) and BCC is sometimes difficult for the clinician and the pathologist, CD10 may be a useful marker for definite diagnosi...

متن کامل

The Usefulness of CD10 in Distinguishing between Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

Background & Objectives:  CD10 is a cell surface enzyme with metalloendopeptidase activity, also known as Common Acute Lymphoblastic Leukaemia Antigen, which mainly serves as a marker for acute lymphoblastic leukemia (ALL). To date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed CD10 expression in cutaneous epithelial neoplasms. Our goal was to d...

متن کامل

Primary Intraosseous Carcinoma of the Maxilla

A primary intraosseous carcinoma (PIOC) is a squamous cell carcinoma arising within the  jawbone andshould be differentiated from a malignant ameloblastoma.  It  is not due to arising from an odontogenic cyst or tumor. The possibility of the lesion being  a metastasis fromanotherprimary site should be considered, and excluded by a careful history and examination. The diagnosis of a PIOC is ra...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • American journal of clinical pathology

دوره 134 1  شماره 

صفحات  -

تاریخ انتشار 2010